Wayne Davis
Research Assistant Professor
Courses:
Genetics and Society
Contact information:
wdavis@biology.utah.edu
801-585-3692
My group is interested in DNA metabolism in C. elegans. Specifically, we are studying the mechanisms of recombination in the germ line. Areas of active research include the mechanisms of crossover interference, gene conversion, synthesis-dependent strand annealing and double-strand break repair. Our deeper understanding has allowed the development of improved techniques for mapping of mutations, inducible activation of gene expression and the development of methods for single copy gene insertion into chromosomes.
Publications:
Davis MW, Morton JJ, Carroll D, Jorgensen EM. (2008). Gene activation using FLP recombinase in C. elegans. PLoS Genet. 4(3):e1000028.
Beg AA, Ernstrom GG, Nix P, Davis MW, Jorgensen EM. (2008). Protons act as a transmitter for muscle contraction in C. elegans. Cell. 2008 Jan 11;132(1):149-60.Morton, J., Davis, M. W., Jorgensen, E. M., and Carroll, D. (2006). Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. PNAS, 103(44):16370-5
Davis, M. W., Hammarlund, M. (2006). "SNP Mapping.", in C. elegans Methods and Applications Kevin Strange, ed. (Totowa NJ Humana Press), 2006.
Davis, M. W.*, Hammarlund, M.*, Harrach, T., Hullett, P., Olsen, S., and Jorgensen, E. M. (2005). Rapid Single Nucleotide Polymorphism Mapping in C. elegans. BMC Genomics, 6, 118.
Hammarlund, M.*, Davis, M. W.*, Nguyen, H., Dayton, D., and Jorgensen, E. M. (2005). Heterozygous insertions alter crossover distribution but allow crossover interference in C. elegans. Genetics, 171(3): 1047-56.
Davis, M. W., Birnie, A. J., Chan, A. C., Page, A. P., and Jorgensen, E. M. (2004). A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans. Development, 131: 6001-6008.
de Bono M., Tobin D.M., Davis M.W., Avery L., and Bargmann C.I. (2002), Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli, Nature, 419(6910): 899-903 .
Bessereau, J.L., Wright, A., Williams, D.C., Schuske, K., Davis, M.W., Jorgensen, E.M. (2001), Mobilization of a Drosophila transposon in the Caenorhabditis elegans germ line, Nature, 413(6851): 70-4.
Fleischhauer, R., Davis, M.W., Dzhura, I., Neely, A., Avery, L., Joho, R.H. (2000), Ultrafast inactivation causes inward rectification in a voltage-gated K+ channel from Caenorhabditis elegans, J Neuroscience, 20(2):511-20.
Davis, M.W., Fleischhauer, R., Dent, J.A., Joho, R.H., Avery, L. (1999), A mutation in the C. elegans EXP-2 potassium channel that alters feeding behavior, Science 286(5449):2501-4.
Dent, Joseph A., Davis, M. Wayne, and Avery, Leon (1997), avr-15 encodes a chloride channel subunit that mediates inhibitory glutamatergic neurotransmission and ivermectin sensitivity in Caenorhabditis elegans, EMBO J, 16: 5867-5879
Davis, M. Wayne, Somerville, Delores, Lee, Raymond Y. N., Lockery, Shawn, Avery, Leon, and Fambrough Douglas M. (1995), Mutations in the Caenorhabditis elegans Na,K- ATPase α-subunit gene, eat-6, disrupt excitable cell function, J Neuroscience, 15(12): 8408-8418.
*co-first author